After college roommates Kyle and Jakob both get bit by radioactive spiders, they find themselves with amazing powers. But when Jakob's insecurities clash with Kyle's easy-going attitude, can the two Spider-Bros be the heroes Kutztown University needs? Does it even need them?

A group of college students discovers that an urban legend is not a myth and release a deadly spirit, housed in an intelligent bird whose mission is to seek revenge on the descendants of their ruthless and heartless ancestors.