A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.

After the apocalypse, some survivors gather together to form a colony. One of them seeks help for his lover, who is still stuck in the outside world with the zombies.

One day, an alien crashes in the yard of Amanda, a teenage loner who loves sci-fi and aliens. The two make friends, but the alien leaves in anger when he sees how aliens are portrayed in movies. He eventually returns when earth faces a great threat.