Can you tell the difference between fact and fiction? Several stories of strange, mysterious and incredible occurrences are chronicled during each episode. It is up to the viewer to decide which stories actually happened and which were completely fabricated by the show’s writers. The answer is revealed by Jonathan Frakes at the conclusion of each episode.

Tim and Eric Awesome Show, Great Job! is an American sketch comedy television series, created by and starring Tim Heidecker and Eric Wareheim, which premiered February 11, 2007 on Cartoon Network's Adult Swim comedy block and ran until May 2010. The program features surrealistic and often satirical humor, public-access television–style musical acts, bizarre faux-commercials, and editing and special effects chosen to make the show appear camp. The program featured a wide range of actors, spanning from stars such as Will Ferrell, John C. Reilly, David Cross, Bob Odenkirk, Will Forte and Zach Galifianakis, to alternative comedians like Neil Hamburger, to television actors like Alan Thicke, celebrity look-alikes and impressionists. The creators of the show have described it as "the nightmare version of television."

A princess in the Amazon rain forests tries to fight a conglomerate threatening the forests by going to Los Angeles. There she links up with a rich kid who tells her that she must get on television to succeed with her mission. Quick as a wink, the two come up with the idea of winning a lambada dance contest.

Both Danny Stein and Tony Vilachi are drug lords in a struggle to gain control of the same territory. Jonathan and Mickey are ex-cons who come in wearing white hats and attempt to settle the dispute.

When a Black oil well worker is killed by a band of California neo-Nazis, his gun-wielding grandmother busts out of her retirement home to avenge him.

A cop goes undercover in a South Carolina high school. With the help of a local narcotics officer, he investigates the drug ring responsible for another cop's death.

A group of students traveling to California are menaced by a vicious group of skin-heads in the Colorado mountains. A WW2 vet living in the mountains comes to their rescue.

A FBI agent going back to his home town. He have to decide if he should be true to his job or take care of his brother who is on the wrong side of the law.

The story of Michael Moore, Shot, Hooker, Joey, and Dennis. Five gangsters who work for a man named Leo. They soon discover they could get more out of life if they could run the streets themselves. Tensions build and loyalty is tested as they plan a hit that could change all of their lives forever.