The series initially starred veteran movie supporting actor Ward Bond as the wagon master, later replaced upon his death by John McIntire, and Robert Horton as the scout, subsequently replaced by lookalike Robert Fuller a year after Horton had decided to leave the series. The series was inspired by the 1950 film Wagon Master directed by John Ford and starring Ben Johnson, Harry Carey Jr. and Ward Bond, and harkens back to the early widescreen wagon train epic The Big Trail starring John Wayne and featuring Bond in his first major screen appearance playing a supporting role. Horton's buckskin outfit as the scout in the first season of the television series resembles Wayne's, who also played the wagon train's scout in the earlier film.

Have Gun – Will Travel is an American Western television series that aired on CBS from 1957 through 1963. It was rated number three or number four in the Nielsen ratings every year of its first four seasons. It was one of the few television shows to spawn a successful radio version. The radio series debuted November 23, 1958. The television show is presently shown on the Encore-Western channel. Have Gun – Will Travel was created by Sam Rolfe and Herb Meadow and produced by Frank Pierson, Don Ingalls, Robert Sparks, and Julian Claman. There were 225 episodes of the TV series, 24 written by Gene Roddenberry. Other contributors included Bruce Geller, Harry Julian Fink, Don Brinkley and Irving Wallace. Andrew McLaglen directed 101 episodes and 19 were directed by series star Richard Boone.

Dick Powell's Zane Grey Theatre, sometimes simply called Zane Grey Theatre, is an American Western anthology series which ran on CBS from 1956 to 1961.

The Lucy Show is an American sitcom that aired on CBS from 1962–68. It was Lucille Ball's follow-up to I Love Lucy. A significant change in cast and premise for the 1965–66 season divides the program into two distinct eras; aside from Ball, only Gale Gordon, who joined the program for its second season, remained. For the first three seasons, Vivian Vance was the co-star. The earliest scripts were entitled The Lucille Ball Show, but when this title was declined, producers thought of calling the show This Is Lucy or The New Adventures of Lucy, before deciding on the title The Lucy Show. Ball won consecutive Emmy Awards as Outstanding Lead Actress in a Comedy Series for the series' final two seasons, 1966–67 and 1967–68.

The Shiloh Ranch in Wyoming Territory of the 1890s is owned in sequence by Judge Henry Garth, the Grainger brothers, and Colonel Alan MacKenzie. It is the setting for a variety of stories, many more based on character and relationships than the usual western.

Daniel Boone is an American action-adventure television series starring Fess Parker as Daniel Boone that aired from September 24, 1964 to September 10, 1970 on NBC for 165 episodes, and was made by 20th Century Fox Television. Ed Ames co-starred as Mingo, Boone's Cherokee friend, for the first four seasons of the series. Albert Salmi portrayed Boone's companion Yadkin in season one only. Dallas McKennon portrayed innkeeper Cincinnatus. Country Western singer-actor Jimmy Dean was a featured actor as Josh Clements during the 1968–1970 seasons. Actor and former NFL football player Rosey Grier made regular appearances as Gabe Cooper in the 1969 to 1970 season. The show was broadcast "in living color" beginning in fall 1965, the second season, and was shot entirely in California and Kanab, Utah.

The tale of trail boss Gil Favor and his trusty foreman Rowdy Yates as they drives cattle across the old west. Along the way they meet up with adventure and drama.

The Big Valley is an American western television series which ran on ABC from September 15, 1965, to May 19, 1969. The show stars Barbara Stanwyck, as the widow of a wealthy nineteenth century California rancher. It was created by A.I. Bezzerides and Louis F. Edelman, and produced by Levy-Gardner-Laven for Four Star Television.

Lawman is an American western television series originally telecast on ABC from 1958 to 1962 starring John Russell as Marshal Dan Troop and featuring Peter Brown as Deputy Marshal Johnny McKay. The series was set in Laramie, Wyoming during 1879 and the 1880s. Warner Bros. already had several western series on the air at the time, having launched Cheyenne with Clint Walker as early as 1955. The studio continued the trend in 1957 with the additions of Maverick with James Garner and Jack Kelly, Colt .45 with Wayde Preston, and Sugarfoot with Will Hutchins. One year later, Warner Bros. added Lawman and Bronco with Ty Hardin. Prior to the beginning of production, Russell and Brown and producer Jules Schermer made a pact to maintain the quality of the series so that it would not be seen as "just another western." At the start of season two, Russell and Brown were joined by Peggie Castle as Lily Merrill, the owner of the Birdcage Saloon, and a love interest for Dan.

The space family Robinson is sent on a five-year mission to find a new planet to colonise. The voyage is sabotaged time and again by an inept stowaway, Dr. Zachary Smith. The family's spaceship, Jupiter II, also carries a friendly robot who endures an endless stream of abuse from Dr. Smith, but is a trusted companion of young Will Robinson

The Lone Ranger is an American western television series that ran from 1949 to 1957, starring Clayton Moore with Jay Silverheels as Tonto. The live-action series initially featured Gerald Mohr as the episode narrator. Fred Foy served as both narrator and announcer of the radio series from 1948 to its finish and became announcer of the television version when story narration was dropped there. This was by far the highest-rated television program on the ABC network in the early 1950s and its first true "hit".

Gunsmoke is an American radio and television Western drama series created by director Norman MacDonnell and writer John Meston. The stories take place in and around Dodge City, Kansas, during the settlement of the American West. The central character is lawman Marshal Matt Dillon, played by William Conrad on radio and James Arness on television.

Bat Masterson is an American Western television series which showed a fictionalized account of the life of real-life marshal/gambler/dandy Bat Masterson. The title character was played by Gene Barry and the half-hour black-and-white shows ran on NBC from 1958 to 1961. The series was produced by Ziv Television Productions, the company responsible for such hit series as Sea Hunt and Highway Patrol.

Alias Smith and Jones is an American Western series that originally aired on ABC from 1971 to 1973. It stars Pete Duel as Hannibal Heyes and Ben Murphy as Jedediah "Kid" Curry, a pair of cousin outlaws trying to reform. The governor offers them a conditional amnesty, as he wants to keep the pact under wraps for political reasons. The condition is that they will still be wanted— until the governor can claim they have reformed and warrant clemency.

The Mod Squad was the enormously successful groundbreaking "hippie" undercover cop show that ran on ABC from September 24, 1968, until August 23, 1973. It starred Michael Cole as Pete Cochren, Peggy Lipton as Julie Barnes, Clarence Williams III as Linc Hayes, and Tige Andrews as Captain Adam Greer. The executive producers of the series were Aaron Spelling and Danny Thomas. The iconic counter-culture police series earned six Emmy nominations, four Golden Globe nominations plus one win for Peggy Lipton, one Directors Guild of America award, and four Logies. In 1997 the episode "Mother of Sorrow" was ranked #95 on TV Guide's 100 Greatest Episodes of All Time.

Laredo is an American Western television series that aired on NBC from September 16, 1965, to April 7, 1967. Laredo stars Neville Brand, William Smith, Peter Brown, and Philip Carey as Texas Rangers. It is set on the Mexican border about Laredo, Texas. The program was produced by Universal Television. The pilot episode of Laredo aired on NBC's The Virginian under the title, "We've Lost a Train". It was released theatrically in 1969 under the title Backtrack. Three episodes from the first season of the series were edited into the 1968 feature film Three Guns for Texas.

Lancer is an American Western series that aired on CBS from September 1968, to May 1970. The series stars Andrew Duggan, James Stacy, and Wayne Maunder as a father with two half-brother sons, an arrangement similar to the more successful Bonanza on NBC.

The rebellious Thracian Spartacus, born and raised a slave, is sold to Gladiator trainer Batiatus. After weeks of being trained to kill for the arena, Spartacus turns on his owners and leads the other slaves in rebellion. As the rebels move from town to town, their numbers swell as escaped slaves join their ranks. Under the leadership of Spartacus, they make their way to southern Italy, where they will cross the sea and return to their homes.

As a Civil War veteran spends years searching for a young niece captured by Indians, his motivation becomes increasingly questionable.

The Adventures of Kit Carson is an American Western series that aired in syndication from August 1951 to November 1955, originally sponsored by Coca-Cola. It stars Bill Williams in the title role as frontier scout Christopher "Kit" Carson. Don Diamond co-starred as "El Toro", Carson's Mexican companion.