Ten players, 300 million KRW prize money! The last survivor of the game will take the money. Contestants from diverse backgrounds compete for survival in this brutal game, in which whatever means necessary are allowed. You can enjoy the complicated mind games as the contestants do politics, tell lies, design plots, or anything that can help them survive.

Lee Ju-ha, the only daughter of a chaebol family, lives a happy life after marrying her ordinary husband Kim Gyu-jin. However, everything collapses after her parents are killed in a hit-and-run accident and she undergoes a heart transplant. As financial support is cut off, her husband and mother-in-law begin to treat her with contempt, and behind the successful beauty business she built, her husband's affair with investor Han Ye-ri is revealed. Betrayed despite trying to protect her family and pushed to the brink of losing everything, she meets Lee Yeon-seok while on the run. Despite a fateful attraction, she chooses revenge over love. To Yeon-seok, who confesses his love, she makes a proposal: seduce her husband's mistress. Will Ju-ha be able to punish Kim Gyu-jin and Han Ye-ri? A dangerous game of love and betrayal begins, heading toward ruin.

No Exit Game Room is a variety show that determines a winner by conducting brain games in a limited space.