Inspired by the true story of indomitable Kuki Gallmann, the film tells of a beautiful and inquisitive woman who had the courage to escape from her comfortable yet monotonous life in Italy to start anew in the African wilderness with her son, Emanuele, and her new husband, Paolo. Gallmann faces great danger there but eventually becomes a celebrated conservationist.

After falling ill, Yesterday learns that she is HIV positive. With her husband in denial and young daughter to tend to, Yesterday's one goal is to live long enough to see her child go to school.