The show follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

Follow the investigations of a team of NYPD forensic scientists and police officers identified as "Crime Scene Investigators".

Walker investigates a murder connected with a missing government weapon. In addition, he tries to track down a teen on the run from a crime syndicate.