Margarita tells the story of an orphaned teenager with a life like a movie, with many doubts and almost no certainty about her story, who, following her wish, will arrive at a very magical place where she can live and fulfill her dreams, without knowing that this house was the place where she was born and that the perfidious Delfina usurped it to build her empire.

María and Javi are two lifelong friends. Even though they have drifted apart over the course of the last year, when María suffers an accident that leaves her at the verge of dying, they reunite and discover that they have always been in love. Now Javi has to decide whether he continues with his new life with an Uruguayan girlfriend, or give a chance to a childhood love that could die out any second.