In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.

An incarcerated black teen, yearning for freedom, gets a chance to escape, which forces him to confront his place in society.