Ten-year-old Hazel Wells has just moved to the big city of Dimmadelphia because of her dad’s new job. On top of being in an unfamiliar environment, it’s the first time she’s been without her brother, Antony, who’s just left for college, leaving her lonely and unsure of herself. All that changes when the pink-and-green-haired neighbors next door reveal that they are no ordinary neighbors…they’re Cosmo and Wanda, fairy godparents! And they’re coming out of retirement to make all of Hazel’s wishes come true.

Centuries after the destruction of Earth, Kentucky Williams and his cyborg companion, C-LA, lead the crew of the Serrano on an intergalactic, flavor-driven adventure to hunt down the last remaining Earth spices. But they too are being hunted by a ghost from C-LA's past.