Onan, a delirious assassin and survivor of the End of Times, is contacted by his shady coalition for his ultimate Mission: To seek and destroy Spassky, whose ungodly Nose has already inhaled entire galaxies and civilizations into complete in-existence... To find Spassky, Onan must first acquire Lucifer's Molar, a rare and priceless drug that might just lure Spassky into a trap. The quest carries him through a bleak world of absurdity: a land patrolled by a gang of pseudo-religious punk vigilantes constantly 'cleansing' citizens inside the confession booth attached to their "truck-church"; through subterranean Goth taverns with grisly showgirls and coke inhalation competitions; across flamboyant transvestite drug lords employing canine bag-men to run deals.

A man-made virus, 'The Killing Strain'-- an out-of-control swine flu-- turns infected humans into raging monsters. As it rapidly spreads, a group of uninfected survivors must make life-or-death decisions before the U.S. military firebombs the area in a desperate attempt contain the contagion. The survivors are unaware that the virus has already reached their group-- by infecting one of them-- and now the merciless metamorphic process has begun.