The boy who wasn't supposed to grow up—Peter Pan—does just that, becoming a soulless corporate lawyer whose workaholism could cost him his wife and kids. During his trip to see Granny Wendy in London, the vengeful Capt. Hook kidnaps Peter's kids and forces Peter to return to Neverland.

While staying at a hotel in England with his grandmother, Helga, a young boy named Luke inadvertently spies on a convention of witches. The Grand High Witch reveals a plan to turn all children into mice via a magical formula. When they discover the eavesdropper, the witches test the formula on him. Now, with the help of Helga and hotel manager Mr Stringer, Luke the mouse must fight back against the witches.

The story of the Buckman family and friends, attempting to bring up their children. They suffer/enjoy all the events that occur: estranged relatives, the 'black sheep' of the family, the eccentrics, the skeletons in the closet, and the rebellious teenagers.