Honey Kisaragi is a high school student at Sainte Chapelle Girls' School. On her 16th birthday, when she returns home, she discovers that her father Takeshi Kisaragi has been kidnapped by the Panther Claw gang because he had discovered a device that could allow the transformation of the human body. That same evening, Honey Kisaragi meets a man with long white hair who gives her the said device. She thus becomes Cutie Honey and fights Panther Claw to save her father. But a new transfer student, Seira Hazuki, will not make her task easy...

An elite superhuman agent must stop a foreign military unit from seizing control of an ancient artifact that holds the key to ultimate power.