A group of tenants and visitors are trapped in a 10-story high-rise apartment building infested with demons who proceed to hunt the dwindling humans down.

Martin Sheen stars as an American newsman in Rome who begins to investigate the appearance of several corpses found throughout Europe with their hands cut off. He soon uncovers not only plots of plutonium theft, but also of nuclear arms deals and dark political schemes.

Nino and Anna grow-up as neighbors and song-writing partners. They gradually fall in love, but eventually go there separate ways. Years later, they end up in the same city.

The story of Nino, a street boy from Naples, and his friend Matumba, a boy from New York who wants to emigrate to Naples.

Karen is a forty-year old woman who works in one of the largest hospitals in the town. She has an affair with Alan, the head physician of the same hospital. One day she meets Dennis, a handsome young man, very self-confident with whom she falls in love.