Set in Springfield, the average American town, the show focuses on the antics and everyday adventures of the Simpson family; Homer, Marge, Bart, Lisa and Maggie, as well as a virtual cast of thousands. Since the beginning, the series has been a pop culture icon, attracting hundreds of celebrities to guest star. The show has also made name for itself in its fearless satirical take on politics, media and American life in general.

Follows a sociopathic genius scientist who drags his inherently timid grandson on adventures across the universe.

Follow the Commander-in-Chief and his eccentric staff as they tackle the kind of crises that Rick Sanchez could never be bothered with - from interdimensional diplomacy to paranormal investigations and unexplained phenomena.

Follow the lives of a group of students at what is possibly the world’s worst community college in the fictional locale of Greendale, Colorado.

The story of a wealthy family that lost everything, and the one son who had no choice but to keep them all together.

Chris Hardwick will lead three celebrity contestants down the ultimate internet wormhole. Culling from the darkest recesses of social media, they will compete to determine who has the funniest take on the day's pop culture.

Dr. Ken is a brilliant physician with no bedside manner. He is always trying to be a good doctor, as well as a good husband and dad to his two kids. However, these good intentions have a way of driving everyone crazy at both work and at home. Luckily, his therapist wife Allison is just the right partner to keep things sane.

A comedic journey into the hilarious world of fantasy roleplaying with Dan Harmon and his Comedian Companions.

An animated comedy focusing on the downtrodden creatures native to Earth’s least-habitable environment: New York City. Whether it’s lovelorn rats, gender-questioning pigeons or aging bedbugs in the midst of a midlife crisis, the awkward small talk, moral ambiguity and existential woes of non-human urbanites prove startlingly similar to our own.

Famous and wealthy funnyman George Simmons doesn't give much thought to how he treats people until a doctor delivers stunning health news, forcing George to reevaluate his priorities with a little help from aspiring stand-up comic Ira.

Rick is a screenwriter living in Los Angeles. While successful in his career, his life feels empty. Haunted and confused, he finds temporary solace in the decadent Hollywood excess that defines his existence. Women provide a distraction to his daily pain, and every encounter brings him closer to finding his place in the world.

Dan Black presents THE ULTIMATE IMPROV SHOW! An all-star cast of improvisers perform the best, funniest and ultimate-est improv show of all time! (Ultimate-est is a word!) Each show will feature a celebrity guest monologist who will tell impromptu stories based off of a random suggestion from the audience. These stories will inspire the funniest improvised comedy scenes you've ever seen, like ever!

Jack Black, Channel 101, and VH1 want to introduce you to their new interactive sketch comedy show: Acceptable.tv. Each week you'll see five mini TV shows made by the Acceptable.tv team.

Mary Shelley's Frankenhole is a stop-motion animated TV series by Dino Stamatopoulos, creator of Moral Orel.

It's a tough gig working for the Water Department, and it's also a tough gig working in Power. Dan Harmon and Ryan Ridley show you why.

Laser Fart began as a joke submission during a light month in 2004. Creator Dan Harmon was able to keep it alive with a Jack Black cameo in episode 2. On the third episode, Harmon teamed up with samurai lensman David Hartman and Channel 101 history was made. Laser Fart delighted audiences with its ironically epic feel and came breathtakingly close to breaking The 'Bu's record for longest running show. Then, in July of 2005, a weary Harmon wrote a ridiculous, slapdash script and the always hungry audience moved down the buffet, never looking back. This coincided with the "takeover" of 101 at the hands of a new generation of leaner, meaner (well, nicer), post-ironic underdogs like J.D. Ryznar, Ryan Ridley, Justin Roiland and the once-cursed Valley Pals. Laser Fart stands as a 101 legend and a cautionary tale: No artist has immunity, no show has true momentum. We can all go at any time.

What can be said about Yacht Rock that hasn't been said by various magazines, newspapers and disc jockeys across the country? J.D. Ryznar and Hunter Stair's saga detailing the unknown mythical origins of a previously obscure genre of music struck the audience like a lightning bolt on its first episode, much like fellow 101 breakout House of Cosbys. Unlike HoC, however, Yacht Rock was never sued by its iconic characters' real life counterparts. In fact, it is said that at one time or another, just about every musician lovingly portrayed in the series has witnessed and enjoyed it behind closed doors. Yacht Rock enjoyed success on levels and in ways previously unattained by 101 shows, its title becoming a household phrase at radio stations, a bin at your local record store and a category on iTunes. But beneath its pop cultural triumph was an artistic one that often went undescribed: Yacht Rock's stories were always clever and sometimes downright genius in their assembly, weaving trivi...

Writer Dan Harmon has his assistant Spencer Crittenden construct a time machine to transport historical figures from the past so he can interview them. The interviewees only survive for a few hours before undergoing a "total protoplasmic disconversion" and collapsing into dust, which Spencer collects in a jar.

Here's a history lesson: From April 2007 until February of 2011, Classroom was Channel 101's longest running show of all time. Tyler Spiers created Classroom in January of 2006 writing, producing and directing the first three episodes. With help from the hilarious Joe Davidson, Spiers started the show as a humble, character-driven pilot and it became the most embraced episodic series, schooling the competition for twelve screenings in a row. With its talented cast of Channel 101 regulars, the creative addition of Mike Rose as writer/producer beginning with Episode 4, and frequent plot hi-jinks, the show maintained its status throughout one of the best seasons of Channel 101. Closing the book with it's thirteenth episode, Classroom leaves behind a legacy of five first-place episodes, thousands of happy audience members, and a show that can teach us all a thing or two about Channel 101 success.

When Phone Sexxers premiered in the summer of 2006 the audience granted the simple show about Phone Sex the honor of another episode. Ryan Ridley and Abed Gheith took their good fortune and ran with it, re-inventing themselves with every episode, right up until the end of the 2006 season. They managed to juxtapose the inner workings of the male phone sex industry with situations ranging from high-rise bloodbaths to the depths of hell, and did it with the kind of class and skill that landed the show Best Editing, Best Special Effects, and Best Writing at the 2006 Channy Awards. In January of 2007, Phone Sexxers ended their legacy with a touching self-cancellation that would make Mike Nichols proud.