Doogie Howser is a doctor. He is also a 16-year-old genius who graduated college at age 10 and finished medical school at age 14. But he is still a teenager, with normal teenage friends and problems. But unlike a normal teenager, he is just learning to drive while also consulting on serious medical cases like heart transplants.

A bunch of cool teenagers who are friends living in California form a rock band, The Dreams. Between gigs, they must deal with all kinds of big and small real-life issues such as school, family life, friends, romance, ambition, ego, jealousy, and big decisions.

Asthmatic teenager Barry Gabrewski is a daydreamer. Troubled by bullying, he escapes into a fantasy world where he is the sidekick to his martial arts hero, Chuck Norris, in a series of high-octane adventures taken right out of his movies. With help from his teacher's wise old uncle, Mr. Lee, Barry learns the finer points of martial arts and enters a karate championship.

A widowed fire chief tries to raise his four children with help from his father-in-law.

When a money mule has a fatal heart attack at a Nevada brothel, the contents of the money vest is hidden by Irene. Her regular customer Johnny is her best bet to be able to retire early.