The show follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

Harmon "Harm" Rabb Jr. is a former pilot turned lawyer working for the military's JAG (Judge Advocate General) division, the elite legal wing of officers that prosecutes and defends those accused of military-related crimes. He works closely with Lt. Col. Sarah Mackenzie, and together they do what needs to be done to find the truth.

Dr. Alan Feinstone has everything: a beautiful wife and a successful career in dentistry. However, when he discovers his wife's affair, he realizes that behind every clean, white surface lies the stench of decay.

A convicted murderer is escorted by marshals on a regular flight from Phoenix to Dallas. Shortly after takeoff, two of his aides, traveling as ordinary passengers, take control and free him. He demands $20 million in bonds upon landing. And a sick passenger, bad weather or mechanical problems won't stop him.

During routine maintenance of a liquid-fuelled ICBM, the fuel tank is penetrated by a falling spanner. The film traces the efforts of the maintenance crew and associated military and civilian personnel to recover the potentially disastrous situation before the fuel tank is sufficiently depressurised that the stack collapses and explodes.

Myra is a trusted courier for drug-lord Anton. When she wants to retire, Anton plans to make sure her retirement is very permanent; as in dead.