6 Athiyayam is an anthology that has 6 stories helmed by 6 different directors. All the stories are based on different genres and are penned in a manner that the movie caters to all the sections of the audience with different artists playing the lead. The stories are correlated and the climax of each story is revealed only in the finale that will keep you on the edge of your seat.

Vellai is a farmer from an economically self-sufficient village. But when he and the villagers take a bank's crop loan, they get caught in debt due to drought and low prices for crops. So few desperate farmers migrate to the city in search of a job. Can they pay off their debt? Or will they give up farming?

A director changes the perception of love for a group of youngsters by narrating how he reclaimed his life because of his now-married lover and her understanding husband.

A young man, on the advice of an agent, lies that he is married, to go to London. But his visa application is rejected and now, he has to follow-up with a string of lies to hide one lie.

Periyar joins the Indian struggle for independence after being disgusted by the injustices of the Hindu caste system. Later, he begins fighting for the rights of Tamilians.

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Velu, who works in a tea shop, fights for justice for his 9-year-old daughter, who has been subjected to sexual assault by two influential upper-caste men during a festive season.. However, when he realizes that people he trusts wanted to cover this up, he decides to fight for justice with the help of his Marxist-leaning friends.