A female CIA agent is assigned to train and lead an all-female squad to Colombia to stop a renegade agent who has hired himself out to a drug cartel.

Chuck Toedan hosts the most controversial show on TV: Live or Die, where deathrow inmates compete against each other for a chance to beat the executioner. However, when he accidentally kills a mob boss of the most feared mafia in the city, a hit man tries to put an end to him and his show once and for all. As a battle of wits and survival ensues, Chuck is forced to engage in the very tactics he uses on his contestants, or die trying.

After a man's sister is killed by two gunmen who seemingly come out of nowhere, he manages to find and kill them. He then discovers that the men he killed were part of a multi-millionaire's bizarre "death game", where someone is hunted through the streets of Los Angeles by teams of killers who get a big-money prize for killing their quarry--and he realizes that now he is "it".