The story of Cleopatra, the fabulous queen of Egypt, and the epic romances between her and the greatest men of Rome, Julius Caesar and Antony. Only a small fragment of this film survives.

When the father of sixteen-year-old Annabelle Leigh (Billie Burke) is killed in a fight, miner John Rawson (Herbert Rawlinson) snatches her away from the scene and takes her to his cabin for the night. In the morning, she insists she was "compromised" by the situation, so he marries her. But after a spat, he tells her to leave and she goes to another city. Annabelle doesn't even know the name of the man she married; however, he strikes it rich and sends her money, which she spends on frivolous entertainment.