John James is a writer; his wife has left him. He moves with his two middle-school children to an isolated house off a dirt road in South Carolina. The property has an Indian burial mound, which fascinates his daughter, Louisa, who's entering puberty.

A boy's life is turned upside down when he learns that he is the last of a group of immortal warriors who have dedicated their lives to fighting the forces of the dark.

In Texas, the aspirant actress Nicole Carrow runs away home to Los Angeles with her boyfriend Jess Hilts. They drive through a shortcut in an old road, and when they park in a rest stop, Jess is abducted by the sadistic driver of an old yellow truck. Along the night, Nicole is threatened by the sick maniac, while mysterious things happen to her in the place.

One year after running away from home, Nicole and Jesse are still missing. When Jesse's brother, Tom, returns home from active duty, he sets out with his friends Marilyn and Jared to locate the lost couple. Their search leads them to the stretch of old highway with a mysterious Rest Stop, where they find themselves in the same predicament as Nicole and Jesse: confronting a madman.

Seth and Jonah are twins with a dangerous ability: telekinesis. Things start to spiral out of control as their classmates die in twisted and bizarre ways. Jealousy begins to divide them and soon they can no longer trust each other, leading up to a horrific battle against themselves.