20 years since their first adventure, Lloyd and Harry go on a road trip to find Harry's newly discovered daughter, who was given up for adoption.

Sam Loudermilk is a recovering alcoholic and substance abuse counselor with an extremely bad attitude about, well, everything. He is unapologetically uncensored, and manages to piss off everyone in his life. Although he has his drinking under control, Loudermilk discovers that when your life is a complete mess, getting clean is the easy part.