ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.

Dealing with a sociopathic school bully, three high school freshmen hire a low-budget bodyguard to protect them, not realizing he is just a homeless beggar and petty thief looking for some easy cash.

Just when George Banks has recovered from his daughter's wedding, he receives the news that she's pregnant ... and that George's wife is expecting too. He was planning on selling their home, but that's a plan that—like George—will have to change with the arrival of both a grandchild and a kid of his own.

After 15 years of marriage, Katie and her husband, Ben, have grown apart. While they keep up the facade of having a contented marriage, mostly to not worry their children, they aren't happy together and argue frequently. While the kids are away at camp, Katie and Ben decide to separate and try to reassess their relationship to see if they should stay together or split up for good. 

Relationship issues arise between a researcher with a theory to explain away all his failed dating experiments, a player who wants out of the game, a deejay whose head spins with thoughts of God, a hoodrat with no street cred, a poet not-so-well-versed in the art of love, and a womanipulator of men.