400 years into the future, disease has wiped out the majority of the world's population, except one walled city, Bregna, ruled by a congress of scientists. When Æon Flux, the top operative in the underground 'Monican' rebellion, is sent on a mission to kill a government leader, she uncovers a world of secrets.

The rookie journalist Vivian seeks Frederick, the caretaker of the oldest cemetery in an undefined country, asking for an interview and the old man tells the story of two "costumers" and both connected by a mysterious secret. The powerful gangster Jimmie Levinson accuses his former partner Paul Pattuchi of stealing a load of cocaine and orders to kill his beloved girlfriend Clarice. Paul is found dead later in a cottage, and Jimmie and his friends and girlfriends are visited during a dinner party by Robert Downing first and then by the sadistic Mortimer and his partner Rick seeking the truth about Paul and a suitcase with a mysterious relic. The second story takes place in the Middle Ages, where the cruel David Deming and his minion Tom Brewster chase the renegade priest James Flynn in the name of the Inquisition but actually trying to force him to reveal the secret of the Eternal Heart to grant immortality.

A woman whose family was brutally murdered when she was little is instructed by her family's ghosts to bring the killers to them so their souls can rest in peace.