The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

A cliché hunchbacked evil scientist's assistant aspires to become a scientist himself, much to the displeasure of the rest of the evil science community.

in 1988, 12 year old boy genius Henry Jameson sends his best friend, George, into the future to discover the resolution of a cliffhanger episode of the hit detective show 'Columbo.' But he loses him somewhere in time. 20 years later, Henry has become a degenerate alcoholic when 12 yr old George appears on his doorstep. Henry is forced to overcome the loser he has become to find a way to send George back to the 80s. Hilarity ensues!