The story of New Jersey-based Italian-American mobster Tony Soprano and the difficulties he faces as he tries to balance the conflicting requirements of his home life and the criminal organization he heads. Those difficulties are often highlighted through his ongoing professional relationship with psychiatrist Jennifer Melfi. The show features Tony's family members and Mafia associates in prominent roles and story arcs, most notably his wife Carmela and his cousin and protégé Christopher Moltisanti.

The exploits of a group of men and women who serve the City of New York as police officers, firemen, and paramedics, all working the same fictional 55th precinct during the 3pm to 11pm shift - the 'Third Watch'.

A New York suburban couple's marriage goes dangerously awry when the wife indulges in an adulterous fling.

After a night of partying with a female stranger, a man wakes up to find her stabbed to death and is charged with her murder.

French nuclear tests irradiate an iguana into a giant monster that viciously attacks freighter ships in the Pacific Ocean. A team of experts, including Niko Tatopoulos, conclude that the oversized reptile is the culprit. Before long, the giant lizard is loose in Manhattan as the US military races to destroy the monster before it reproduces and it's spawn takes over the world.

After a car crash, police detective Sam Tyler mysteriously finds himself transported back to 1973 and still working as a detective.

Dedicated environmental lawyer Lucy Kelson goes to work for billionaire George Wade as part of a deal to preserve a community center. Indecisive and weak-willed George grows dependent on Lucy's guidance on everything from legal matters to clothing. Exasperated, Lucy gives notice and picks Harvard graduate June Carter as her replacement. As Lucy's time at the firm nears an end, she grows jealous of June and has second thoughts about leaving George.

The secret US abduction of a suspected terrorist from his Middle East homeland leads to a wave of terrorist attacks in New York. An FBI senior agent and his team attempt to locate and decommission the enemy cells, but must also deal with an Army General gone rogue and a female CIA agent of uncertain loyalties.

Set in a world where the concept of lying doesn't exist, a loser changes his lot when he invents lying and uses it to get ahead.

When a rich man's son is kidnapped, he cooperates with the police at first but then tries a unique tactic against the criminals.

Bertram Pincus, a cranky, people-hating Manhattan dentist, develops the unwelcome ability to see dead people. Really annoying dead people. Even worse, they all want something from him, particularly Frank Herlihy, a smooth-talking ghost, who pesters him into a romantic scheme involving his widow Gwen. They are soon entangled in a hilarious predicament between the now and the hereafter!

Psychiatrist Ann Hecker is ending one relationship and possibly starting an important new one, while finding that some of the sexual exploits her patients relate are weighing on her. Turning to a married friend from her research days for guidance, she finds his help increasingly important when a female patient is murdered and it turns out that her new boyfriend was also seeing the dead woman.