At a national park in Kenya, English game warden George Adamson and his wife, Joy, care for three orphaned lion cubs. After the two larger lions are shipped off to a zoo in the Netherlands, the smallest of the three, Elsa, stays with the couple. When Elsa is blamed for causing an elephant stampede in the nearby village, head warden John Kendall demands the young lion either be trained to survive in the wilds of the Serengeti or be sent to a zoo.

Having spent 10 years in prison for nationalist activities, Shack Twala is finally ordered released by the South African Supreme Court but he finds himself almost immediately on the run after a run-in with the police. Assisted by his lawyer Rina Van Niekirk and visiting British engineer Jim Keogh, he heads for Capetown where he hopes to recover a stash of diamonds, meant to finance revolutionary activities, that he had entrusted to a dentist before his incarceration. Along the way, they are followed by Major Horn of the South African State security bureau and it becomes apparent that he has no intention of arresting them until they reach their final destination

When embittered safari guide David Kirby accepts a fateful commission to lead a hunting trip for wealthy and ruthless American Mitchell Gifford, tragedy soon intervenes and the big game hunt becomes a man hunt.