Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

Thanks to a Japanese scientist's invention of synthetic blood, vampires have progressed overnight from legendary monsters to fellow citizens. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides. But in the small Louisiana town of Bon Temps, the jury is still out.

Drew is an assistant director of personnel in a Cleveland department store and he has been stuck there for ten years. Other than fighting with co-worker Mimi, his hobbies include drinking beer and not being able to get dates. To make a few extra bucks he has a micro-brewery going in his garage with his buddies.

A comedy about the triumphs and tribulations of marriage and friendship from very different perspectives. It's about the funny – and sometimes annoying – things that happen between husbands, wives, parents, children, neighbors and friends day after day after day. The show focuses on Eddie and Joy Stark, a couple married for 23 years who live in Philadelphia, Pennsylvania.

Claude Casey moved up in the secretarial world of television news, from temp to the anchor's desk. After her boss hires her full time, Claude realizes she may be in over her head in this world of assistants fighting to get ahead. But Claude is determined to prove that though she may not be perfect, she's not going down without a fight.

Ryan King, a recent widower and sports talk radio host ready to get back to work after the loss of his wife. Ryan's alpha-male boss, Stephen, has a different plan in store for Ryan, making him attend grief counseling before returning to the air. A reluctant Ryan finds himself in a support group for "life change," where he meets an oddball cast of characters, all with their own backstories filled with varying degrees of loss.

It's not every family that's brought closer together by divorce, but then again, the Fishers are anything but typical.

The archangel Gabriel returns to try to destroy the human race he despises so much, with the help of a suicidal teen and the opposition of the angel Danyael.

A cunning psychopath with more than an axe to grind murders the kindly Mailman in a small, placid suburban town. Darius Foxx scarred for life as a young boy by seeing his parents brutally murdered, comes back to town as the new Mailman to torment his younger brother, Daniel, and Daniel's adopted family.