George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.

In sleepy Santa Rosa, restless young Charlie’s world brightens when her sophisticated Uncle Charlie arrives for a long visit. But as his behavior grows increasingly strange, she begins to suspect that her beloved uncle may be hiding a terrible secret—and that danger has quietly entered her home.

Two employees at a gift shop can barely stand one another, without realising that they are falling in love through the post as each other's anonymous pen pal.

After breaking up with her fiancé, a gym teacher returns to work at a women's college, but a legal loophole allows him to enroll as one of her students.

Unfounded suspicions lead a married couple to begin divorce proceedings, whereupon they start undermining each other's attempts to find new romance.

An Episcopal Bishop, Henry Brougham, has been working for months on the plans for an elaborate new cathedral which he hopes will be paid for primarily by a wealthy, stubborn widow. He is losing sight of his family and of why he became a churchman in the first place. Enter Dudley, an angel sent to help him. Dudley does help everyone he meets, but not necessarily in the way they would have preferred. With the exception of Henry, everyone loves him, but Henry begins to believe that Dudley is there to replace him, both at work and in his family's affections, as Christmas approaches.

After a rapid engagement, a dowdy daughter of a chemist weds an industrialist, knowing little of his family or past. He transforms her into an elegant society wife, but becomes enraged whenever she asks about Michael, his mysterious long-lost brother.

Down-on-his-luck John Ellman is framed for a judge's murder. After he's convicted and sentenced to death, witnesses come forth and prove his innocence. But it was too late for a stay to be granted and Ellman is executed. A doctor uses an experimental procedure to restore him to life, though the full outcome is other than expected.

After an innocent man is executed in a case he was responsible for, a Scotland Yard superintendent finds himself investigating the murder of his key witness.

Mine owner William Sharon keeps having his gold shipments held up by a gang of bandits. Sharon hires banker Charles Crocker, who happens to have connections in the Central Pacific Railroad, to build a spur line from Virginia City to Carson City, so that the gold can be shipped by railroad. Silent Jeff Kincaid is the railroad engineer. However there is opposition to the railroad, chiefly from another mine owner, Big Jack Davis.

Kitty Carroll, an attractive store model, volunteers to become a test subject for a machine that will make her invisible so that she can use her invisibility to exact revenge on her ex-boss.

Colonel Ferris, a wealthy farmer in northern California, is strongly opposed to hydraulic mining, a new method developed during the gold rush of the 1870's, which is flooding the area's prosperous farmlands. Despite Ferris' political stance, Jared Whitney, a mining engineer from the East, becomes friends with the colonel's son Lance and falls in love with his daughter Serena. Family tensions deepen when the colonel's brother Ralph gives up farming to go to San Francisco to work for his wife Rosanna's father, Harrison McCooey, a leader in the mining venture. When Lance follows Ralph, the colonel, focusing his anger on Jared, forbids him to see Serena.

Grant Jordan, bachelor botany professor, marries Katie, a widow with three kids, despite the machinations of Grant's former girlfriend Minna. But on the wedding day, Aunt Jo, who was to babysit, breaks a leg; so the kids come along on the honeymoon.

An opportunistic Texas gambler and the exiled Creole daughter of an aristocratic family join forces to achieve justice from the society that has ostracized them.

While watching from her train window, Nikki Collins witnesses a murder in a nearby building. When she alerts the police, they think she has read one too many mystery novels. She then enlists a popular mystery writer to help her solve the crime on her own, but her sleuthing attracts the attentions of suitors and killers.

Beautiful young Virginian Jane steps down from her proper aristocratic upbringing when she marries down-to-earth surveyor Matt Howard. Matt joins the Colonial forces in their fight for freedom against England. Matt will meet Jane's father in the battlefield.

Mary Smith decides after a lifetime of being a shut-in to do something wild while her father is out campaigning for the presidency, so she takes off for the family's home in West Palm Beach and inadvertently becomes romantically entangled with earnest cowboy Stretch Willoughby. Neither the dalliance nor the cowboy fit with the upper class image projected by her esteemed father, forcing her to choose.

Huckleberry Finn, a rambunctious boy adventurer chafing under the bonds of civilization, escapes his humdrum world and his selfish, plotting father by sailing a raft down the Mississippi River.

Con men Calvin Churchill and Clip McGurk know how to fix a horse-race or boxing match. Calvin wants to go straight and win back his estranged wife, but first the men must dodge a dogged IRS agent and bilk a bunch of aviation investors out of the backing boodle for a balloon excursion into the stratosphere.

A kindly, enthusiastic, newly-arrived American immigrant from Hungary is forced to turn to a life of crime after his face is badly disfigured in a hotel fire.