In the poverty-stricken favelas of Rio de Janeiro in the 1970s, two young men choose different paths. Rocket is a budding photographer who documents the increasing drug-related violence of his neighborhood, while José “Zé” Pequeno is an ambitious drug dealer diving into a dangerous life of crime.

The series is based on the award-winning Brazilian film City of God, which itself was nominated for Oscars in four categories, including Best Director for Fernando Meireles. Based on the story of two friends, Laranjinha and Acerola, who live adventurous and dangerous lives in a Rio de Janeiro slum, 'City of Men' brings into sharp relief the condition of children and adolescents in these areas, realistically yet with a dose of humor.

Priest Marcelo Rossi visits a juvenile correction center, and gives Paulo, one of the interns, a Bible. He starts reading the story of St. Paul.

Yuda, a Chinese immigrant, and his adopted son Kirin, who he saved being eaten by a tiger in the jungle, stand at the head of a massive pirated goods operation that brings in both money and influence. But their empire is crumbling, as corrupt politicians and rival gangs seek to end their power in the city. Yuda is soon got arrested and his dedicated son tries his best to save not just the family business, but his father's reputation.

Following the suicide of his father, haunted by inner demons and his hatred for the world, Santiago decides to escape from Lima and take refuge in Máncora, a beach to the north of Peru where it is always summer.

Two young boys, Laranjinha and Acerola, living in Cidade de Deus, one of the most violent neighborhoods in Rio de Janeiro, need some money to go to a concert. The "easiest" (and most dangerous) way to get it is working for some drug-dealers.