Best Friends follows the life of a group of friends at their high school ‘Spangalis College’. Inside and outside of school exciting and challenging experiences take place. Growing up is never easy; every character has its own, unique story of love, friendship, loneliness, sorrow, discovery. There is drama and joy in school, family, teachers, parents, divorce, bullying, and always dreams for the future.

Former Amsterdam police detective Floris Wolfs has been transferred to the police department of the south-Dutch country town Maastricht. His metropolitan experience nicely complements the local expertise of his new country colleagues, who know the folks. Slowly he fits in, while solving countless crimes together with his female partner Eva van Dongen.

Two wealthy young brothers living on a plush estate give refuge to a petty criminal who is on the run from the police. Neither the boys' parents or their staff know about the fugitive's presence, which leads them open to exploitation. Sure enough, they soon discover the fugitive has no intention of leaving.

Two thirty-somethings have been drinking and dancing all night and decide to go home together. During the bike ride home, they sober up and discover they might not like each other that much after all...