Bill Nye explores science and its impact on politics, society and pop culture. Each episode tackles a topic from a scientific point of view, dispelling myths, and refuting anti-scientific claims that may be espoused by politicians, religious leaders or titans of industry.

Late-night radio host Dale Sweeney's usual line up of odd-ball, conspiracy-obsessed callers is interrupted by a panicked phone call in an indecipherable language. When FBI agents arrive investigating the call, Dale enlists his friends help to uncover what he hopes is the amazing identity of this first time caller.