The show follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

The lives of staff in the womens' health clinic of a fictitious hospital in Philadelphia.

Laura Baxter is a young woman, literally a "sleeping beauty," who suffers from a medical condition called "parasomnia." A childhood accident victim, she is actually sleeping her life away, awakening briefly on rare occasions. Art student Danny Sloan falls in love with her, unaware that her hospital neighbor, a terrifying mass murderer and mesmerist named Byron Volpe has other, more sinister plans.

When a group of poachers is found mauled to death in the woods of the Pacific Northwest -- mirroring a grisly slaying that happened years ago, known as the "Echo Mountain Massacre" -- angry locals are convinced that the infamous Sasquatch is to blame. But that doesn't stop four passionate high school students from making a plea to spare the creature's life.