Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Eight people embark on an expedition into the Congo, a mysterious expanse of unexplored Africa, where human greed and the laws of nature have gone berserk.

Rescuers try to reach plane crash victims that are trapped on an isolated Mexican island populated by mutant baboons. Ron Perlman stars as a troubled guide hired to lead the mission.