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Two homicide detectives are on a desperate hunt for a serial killer whose crimes are based on the "seven deadly sins" in this dark and haunting film that takes viewers from the tortured remains of one victim to the next. The seasoned Det. Somerset researches each sin in an effort to get inside the killer's mind, while his novice partner, Mills, scoffs at his efforts to unravel the case.

The murderous, backwoods Firefly family take to the road to escape the vengeful Sheriff Wydell, who is not afraid of being as ruthless as his target.

After Faye and her psychotic boyfriend, Vince, successfully rob a mob courier, Faye decides to abscond with the loot. She heads to Reno, where she hires feckless private investigator Jack Andrews to help fake her death. He pulls the scheme off and sets up Faye with a new identity, only to have her skip out on him without paying. Jack follows her to Vegas and learns he's not the only one after her. Vince has discovered that she's still alive.

Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.