Tsuna, a timid junior high student, is a failure at school, sports, and social life. But everything around Tsuna has been completely changed when a baby called Reborn, who claims to be an Italian hit man from Vongola family shows up! Reborn was sent to groom Tsuna for his future life as a mafia boss of the family!

Ginko, a Mushi master, travels from place to place researching the Mushi and helping people who are suffering because of it.

Aya Akabane is anything but typical. She's arrogant, believes her bra is a fashion accessory that's meant to be worn in public, and takes out her aggression on her closest friends – especially poor Konatsu, who is frequently picked up and spun around by her ponytail. Together with her friends, Aya enjoys an action-packed, event-filled high school life, whether she's trying to steal the panties her friends are wearing or secretly trying to film her classmates' underwater!

Nina, thinking it was a lolly, swallows an object called "Crystal Pearl". But the candy turns out to be a test for the magicians. To retrieve the crystal, a special medicine has to be made so now Zero and Ichii, the magicians, have to protect her from others while waiting for the medicine to be completed.

Naoko-san is an alien from the planet Yuri, who is plotting to conquer the Earth by yurifying it. Misuzu is a junior high girl and is always troubled by Naoko-san, who lives on the roof of her house. They hear rumors that a molester is wandering around in the area, so they decide to investigate.

Naoko-san is an alien from the planet Yuri, who is plotting to conquer the Earth by yurifying it. Misuzu is a junior high girl and is always troubled by Naoko-san, who lives on the roof of her house.