Mariana Cantú and Silvana Del Valle are twin sisters who were separated at birth. After 11 years, the twins meet again and Silvana proposes to Mariana to be part of 'Cómplices al Rescate'. Together they will learn about friendship and love.

Rodrigo Junquera finds out he is close to death, he decides to ask the nanny of his young child, Virginia Martínez, a beautiful and honest woman, to marry him with the intention of preparing the road so she can look after his children when he's gone. Virginia has to deal with the contempt of Rodrigo's children who acuse her of being an ambitious woman who married their father for his money. Virginia is in love with Rodrigo's eldest son, Carlos Alberto, who has come to mistreat her after finding out she married his dad.

Valentina and Sebastián—known as "Los Camaleones"—are manipulated by "El Amo" into stealing artworks and valuable jewelry worth millions of dollars; if they fail to meet his demands, he wields enough power to kill their only loved ones, who are currently imprisoned because of Augusto Ponce de León. Ponce de León is the police chief—and Solange’s father—as well as a womanizer estranged from Francisca Campos; he is in charge of the "Camaleón" case, which he must solve to secure a political position and gain ever-increasing power.

Serafín is a Mexican children's telenovela produced by José Alberto Castro for Televisa and originally broadcast on Canal de las Estrellas from August 30 to December 17, 1999. It stars Maribel Guardia, Eduardo Santamarina, Jordi Landeta, and features the voice of María Fernanda Morales as Serafín. The telenovela was the first Mexican production to incorporate digitally created animated characters into a live-action telenovela. The story follows Serafín, a cheerful but mischievous little angel who is sent to Earth to learn how to become a Guardian Angel. In Mexico City, he meets Pepe, an unhappy boy living with his mother, grandfather, and abusive stepfather. Determined to bring hope and happiness into Pepe's life, Serafín helps him and his friends overcome family conflicts, fear, and adversity while teaching lessons about love, friendship, kindness, and faith.